Fri May 10 2024

54 articles - From Friday May 03 2024 to Friday May 10 2024

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Inflamm Bowel Dis

Pediatric to Adult Transition in Inflammatory Bowel Disease: Consensus Guidelines for Australia and New Zealand.

A multidisciplinary group devised consensus statements to optimize pediatric to adult transitional care for adolescents with IBD. These guidelines should support improved and standardized delivery of IBD transitional care within Australasia.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews

Pancreas

Endotherapy for the proximal migration of pancreatic stents: A systematic review.

Endoscopy is an effective method for the treatment of proximal displacement of pancreatic stents with acceptable complication rate.

Pubmed   Journal   ReadQx 

Pancreatology

Contrast-enhanced endoscopic ultrasound likely does not improve diagnostic adequacy during endoscopic ultrasound guided tissue acquisition: A systematic review and meta-analysis.

Non-randomized studies indicated differences in favor of contrast-enhanced EUS, randomized studies showed no difference in diagnostic adequacy, accuracy or sensitivity when using CEH-EUS.

Pubmed   Journal   ReadQx 


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Accuracy of energy and nutrient intake estimation versus observed intake using four technology-assisted dietary assessment methods: a randomized crossover feeding study.

Under controlled conditions, Intake24, ASA24, and mFR-TA estimated average energy and nutrient intakes with reasonable validity, but intake distributions were estimated accurately by Intake24 only (energy and protein). This study may inform considerations regarding instruments of choice in future population surveillance.

Pubmed   Journal   ReadQx 

Adiposity, immunity, and inflammation: interrelationships in health and disease: A report from 24th annual Harvard nutrition obesity symposium, June 2023.

This manuscript seeks to synthesize and present key findings from the symposium highlighting new research and novel disease-specific advances in the field. Better understanding the interaction between metabolism and immunity offers promising preventative and treatment therapies for obesity-related immunometabolic diseases.

Pubmed   Journal   ReadQx 

Assessment of the prevalence of inadequate iron intakes in premenopausal females based on the reference values of the European Food Safety Authority using cross-sectional food consumption data.

This study provided an example for using the PA method by using additionally derived information on the full requirement distribution underlying EFSA's reference values. Results showed once more the unsuitability of the EAR cut-point method to calculate the prevalence of iron inadequacy in premenopausal females. Hence, we recommend that institutions deriving dietary reference values provide al information needed to use the correct method to determine inadequate intakes in the population.

Pubmed   Journal   ReadQx 

Dietary pattern and diversity analysis using DietDiveR in R: a cross-sectional evaluation in the National Health and Nutrition Examination Survey.

DietDiveR enables users to visualize dietary data and conduct data-driven dietary pattern analyses using R to answer research questions regarding diet. As a demonstration of this toolkit, we explored the diversity of nuts, seeds, and legumes consumption to highlight some of the ways DietDiveR can be used for analyses of dietary diversity.

Pubmed   Journal   ReadQx 

Growth and body composition of infants born moderate-to-late preterm fed an protein- and mineral-enriched postdischarge formula compared with a standard term formula up to 6 months corrected age, a randomized controlled trial.

Infants born moderate-to-late preterm demonstrated modest increases in length, head circumference, lean mass, and bone mineral content when fed PDF compared to STF for 6 months after TEA. Clinical trial register International Clinical Trial Registry Platform ( as NTR5117 (old-NTR) and NTR NL4979 (new-NTR) .

Pubmed   Journal   ReadQx 

Hemp seed protein and its hydrolysate vs. casein protein consumption in adults with hypertension: a double-blind crossover study.

These results suggest that hemp protein consumption, as well as in combination with bioactive peptides, may have a role in the dietary management of hypertension.

Pubmed   Journal   ReadQx 

Life Expectancy Gains from Dietary Modifications: A Comparative Modelling Study in Seven Countries.

A sustained change from country-specific typical dietary pattern patterns to longevity-optimized dietary changes, more feasible dietary changes, or optimized vegan dietary changes, are al projected to result in substantial life expectancy gains across ages and countries. These changes included more whole grains, legumes, and nuts, and less red/processed meats and sugars and sugar-sweetened beverages. The largest gains from dietary changes would be in the United States.

Pubmed   Journal   ReadQx 

Reconsidering the pre-eminence of dietary leucine and plasma leucinemia for predicting the stimulation of postprandial muscle protein synthesis rates.

In this perspective, we propose a re-evaluation of the pre-eminent role of these leucine variables in the stimulation of postprandial MPS. We view the development of a more complex intellectual framework now a priority if we are to see continued progress concerning the mechanistic regulation of postprandial muscle protein turnover, but also consequential from an applied perspective when evaluating the value of novel dietary protein sources.

Pubmed   Journal   ReadQx 

The association between serum methylmalonic acid, cobalamin-related biomarkers, and long-term mortality risk in cancer survivors: a prospective cohort study.

Serum MMA was associated with long-term mortality risk in adult cancer survivors, which was more significant among individuals with higher levels of serum cobalamin. These findings suggest that mortality related to MMA was attributed to the insufficient flux of MMA metabolism, not cobalamin deficiency.

Pubmed   Journal   ReadQx 

Inflamm Bowel Dis

Infliximab Tissue Concentrations in Patients With Stable Ulcerative Colitis Are Correlated With More Durable Infliximab-associated Disease Remission.

These findings support data generated in patients with Crohn's disease plasma infliximab concentrations are reflective of infliximab exposure in tissue in the UC patient in remission, but not for those with active disease. Increasing tissue concentrations in the noninflamed tissues may improve durability of infliximab. Neither plasma nor tissue TNF-α appear to correlate with UC disease activity. Larger follow-up studies would be of benefit.

Pubmed   Journal   ReadQx 

Oncostatin M Induces a Pro-inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts.

Human SEMFs overexpress OSMR in an inflammatory microenvironment. Oncostatin-M may promote inflammation in IBD via its stimulatory effects on SEMFs, which primarily involve chemoattraction of immune cells to the intestinal mucosa.

Pubmed   Journal   ReadQx 

Pharmacologic Anticoagulation Is Associated With a Lower Risk of Recurrent Venous Thromboembolic Events During Janus Kinase Inhibitor Use for Patients With a Prior Thrombosis.

These results suggest that for patients with a prior VTE history there is a high risk for recurrent VTE while receiving JAK inhibitors. Concurrent use of AC with JAK inhibitors appears to be protective against recurrent VTEs in this population.

Pubmed   Journal   ReadQx 

J Crohns Colitis

Colorectal cancer in inflammatory bowel disease: a review of the role of gut microbiota and bacterial biofilms in disease pathogenesis.

Whether biologics and other IBD-targeted therapies can decrease the progression towards dysplasia and CRC via mechanisms independent of inflammation is still unknown. Further research is warranted to identify potential new microbial targets of therapy for chemoprevention of dysplasia and CRC in IBD.

Pubmed   Journal   ReadQx 

Etrasimod for the Treatment of Ulcerative Colitis: Analysis of Infection Events From the ELEVATE UC Clinical Program.

Patients receiving etrasimod demonstrated no increased risk of infection. The incidence of serious infections and herpes zoster was similar in each group. Among patients receiving etrasimod, no association between ALC <0.5 × 109/L and infection events was observed. Longer-term follow-up will further characterize the etrasimod safety profile.

Pubmed   Journal   ReadQx 

Fecal transplantation for ulcerative colitis from diet conditioned donors followed by dietary intervention results in favorable gut microbial profile compared to fecal transplantation alone.

FMT from diet conditioned donors followed by the UCED led to microbial alterations associated with favorable microbial profile which correlated with decreased fecal calprotectin. Our findings support further exploration of additive benefit of dietary intervention for both donors and patients undergoing FMT as a potential treatment of UC.

Pubmed   Journal   ReadQx 

Fibrosis-related transcriptome unveils a distinctive remodeling matrix pattern in penetrating ileal Crohn's disease.

Despite the histopathological similarities in fibrosis between stricturing and penetrating ileal Crohn's disease, their fibrosis-related transcriptomic profiles are distinct. Penetrating disease exhibits a distinctive transcriptomic landscape related to enhanced matrix remodeling.

Pubmed   Journal   ReadQx 

Pan-enteric Crohn's capsule (Eliakim) score reliability and responsiveness to change in active Crohn's disease.

ES is a reliable scoring system in assessing pan-enteric mucosal inflammation in active CD, and might have a better responsiveness to clinical/biochemical change over time compared to LS.

Pubmed   Journal   ReadQx 

The effect of non-pooled multi-donor faecal microbiota transplantation for inducing clinical remission in patients with chronic pouchitis: Results from a multicentre randomised double-blinded placebo-controlled trial (MicroPouch).

Non-pooled multi-donor FMT was comparable to placebo in inducing clinical remission in patients with chronic pouchitis but showed a clinically relevant increase in adverse events compared to placebo.

Pubmed   Journal   ReadQx 

Liver Transpl

Psychiatric diagnoses are common after liver transplantation and associated with increased healthcare utilization and patient financial burden.

Over 1 in 4 LTRs had a psychiatric diagnosis in a large national cohort, yet nearly a quarter received no treatment. LTRs with psychiatric diagnoses experienced increased healthcare utilization and higher financial liability. Sociodemographic and clinical risk factors could inform high-risk subgroups who may benefit from screening and mitigation strategies.

Pubmed   Journal   ReadQx 

The future of liver transplantation in the United States: Ongoing optimism and concerns with a prescription for change.

■■■■.

Pubmed   Journal   ReadQx 

Pancreas

Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras-driven pancreatic cancer model.

These findings show the loss of AHR results in heightened Kras-induced PanIN formation, through modulation of immune cells within the pancreatic tumor microenvironment.

Pubmed   Journal   ReadQx 

Clinical significance of MUC-4 and associated proteins in Pancreatic and Periampullary Cancers.

Differential expression of MUC-4 in pancreatic tumor tissues can help to differentiate PDAC from benign conditions.

Pubmed   Journal   ReadQx 

Early Hypophosphatemia as a Prognostic Marker in Acute Pancreatitis.

Serum phosphate is infrequently measured in patients with AP and shows promise as a rapid, inexpensive, and early prognostic marker for worse outcomes of AP.

Pubmed   Journal   ReadQx 

Essential Fatty Acid Deficiency is Common after Total Pancreatectomy and Islet AutoTransplantation.

One-third of individuals had EFAD 1 year post-TPIAT, highlighting the need for systematic monitoring. Older age at transplant increased risk and adults were more affected than children. Other diagnoses affecting intestinal health may further increase risk for EFAD.

Pubmed   Journal   ReadQx 

Lipase-to-Amylase Ratio for the Prediction of Clinically Relevant Postoperative Pancreatic Fistula following Pancreaticoduodenectomy.

Postoperative drain fluid LAR represents a reliable predictor for the development of CR-POPF. With early prognostication, the postoperative care of patients deemed at risk of developing high-grade fistulas may be optimised.

Pubmed   Journal   ReadQx 

Modulation of nuclear receptor 4A1 expression improves insulin secretion in a mouse model of chronic pancreatitis.

Modulating NR4A1 expression can be a promising therapeutic strategy to improve insulin secretion in CP.

Pubmed   Journal   ReadQx 

Phenotypic, genomic, and transcriptomic heterogeneity in a pancreatic cancer cell line.

MIA PaCa-2 is comprised of cells with distinctive phenotypes, heterogeneous genomes, and differential transcriptomic profiles, suggesting its suitability as a model to study the underlying mechanisms behind pancreatic cancer heterogeneity.

Pubmed   Journal   ReadQx 

Quality of Life Following TPIAT: A Patient Experience Survey.

TPIAT resulted in improved self-reported QOL in most patients, although post-operative physical and mental QOL are less compared to the average healthy United States adult.

Pubmed   Journal   ReadQx 

Research progress on the mechanism of acute hypertriglyceridemic pancreatitis.

This article presents a comprehensive review of the evolving research on HTGP pathogenesis, encompassing lipid synthesis and metabolism, calcium signal transduction, inflammatory mediators, endoplasmic reticulum stress, autophagy, mitochondrial injury by fatty acids, oxidative stress response, genetic factors, and gene mutations. By unraveling the intricate mechanisms underlying HTGP, this article aims to enhance physicians' understanding of the disease and facilitate the development of potential targeted pharmacological interventions for patients.

Pubmed   Journal   ReadQx 

Screening of amino acids as a safe energy source for isolated rat pancreatic acini.

Alanine and glutamate are safe and effective energy sources for mitochondria of pancreatic acinar cells.

Pubmed   Journal   ReadQx 

Severity of gallstone, sludge or microlithiasis induced pancreatitis - all of the same?

Microlithiasis and sludge induce gallstone-equivalent impaired liver function tests and induce pancreatitis with similar severity compared with gallstone-induced acute biliary pancreatitis.

Pubmed   Journal   ReadQx 

Syndecan-1 Levels and Early Positive Fluid Balance Are Associated with Disease Severity in Acute Pancreatitis.

SAP is associated with high positive fluid balance in the early stages of treatment. Although increased in SAP, syndecan-1 was not independently associated with SAP when controlling for fluid balance and APACHE-II score.

Pubmed   Journal   ReadQx 

The Population-level Prevalence of Exocrine Pancreas Insufficiency and the Subsequent Risk of Pancreatic Cancer.

Despite a low prevalence, patients with EPI may have a higher risk of PDAC and many of these patients with EPI were not on PERT. PERT did not appear to impact incident PDAC risk after an EPI diagnosis.

Pubmed   Journal   ReadQx 

The role of gut microbiota and innate immune response in an autoimmune pancreatitis model.

The mouse model demonstrated the involvement of intestinal microbiota in pancreatitis, and LG administration suppressed pancreatitis, possibly through TLR7 signaling in PMs. LG may be a helpful probiotic for treating AIP.

Pubmed   Journal   ReadQx 

Pancreatology

Development of clinical screening tool for exocrine pancreatic insufficiency in patients with definite chronic pancreatitis.

We developed two CART models that were integrated into one digital screening tool to assess for EPI in patients with definite CP and with two to six input variables needed for predicting EPI status.

Pubmed   Journal   ReadQx 

Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling.

We identified several new circRNAs with biomarker potential in surgically treated PDAC, three of which showed an independent prognostic value. We also found that ciRS-7 is absent in cancer cells but abundant in tumor microenvironment and may hold potential as marker of activated stroma.

Pubmed   Journal   ReadQx 

Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation.

CAFs express high levels of versican V0/V1 in primary and liver metastatic PDAC tumours and versican V0/V1 supports fibroblast proliferation.

Pubmed   Journal   ReadQx 

Identification of pancreatic cancer risk factors from clinical notes using natural language processing.

Rule-based NLP algorithms applied to unstructured clinical notes are highly sensitive for automated identification of PDAC risk factors. Further validation in a large primary-care patient population is warranted to assess real-world utility in identifying HRIs for pancreatic cancer screening.

Pubmed   Journal   ReadQx 

Implications of pregnancy on MCN of the pancreas: A multicentric case-control study.

Perigestational MCN are associated to increased cyst diameter, and in the subset of patients affected by MCN during gestation a high rate of growth was observed. Patients with a MCN and pregnancy desire should undergo multidisciplinary counselling.

Pubmed   Journal   ReadQx 

K-ras mutation detected by peptide nucleic acid-clamping polymerase chain reaction, Ki-67, S100P, and SMAD4 expression can improve the diagnostic accuracy of inconclusive pancreatic EUS-FNB specimens.

K-ras mutation detection via peptide nucleic acid-clamping polymerase chain reaction is a stable and accurate method for distinguishing between pancreatic ductal adenocarcinoma and non-pancreatic ductal adenocarcinoma lesions. A classification tree using K-ras mutation, Ki-67, S100P, and SMAD4 helps increase the diagnostic accuracy of cases that are histologically difficult to diagnose.

Pubmed   Journal   ReadQx 

The effect of steroid therapy on pancreatic exocrine function in autoimmune pancreatitis.

The inflammatory involvement of the head of the pancreas is associated with PEF severity, as well as PEF improvement after treatment with steroids in patients with AIP.

Pubmed   Journal   ReadQx 

The epidemiology of acute pancreatitis in tasmania over a 12-year period: Is this a disease of disadvantage?

This is the first Australian study providing robust evidence that AP incidence is increasing and is at the upper limit of population-based studies worldwide. This increased incidence is greatest in socio-economically disadvantaged areas, meriting further research to develop targeted, holistic management strategies.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Diving into dietary pattern and dietary diversity analyses.

Pubmed   Journal   ReadQx 

Predicting total energy expenditure.

Pubmed   Journal   ReadQx 

Inflamm Bowel Dis

Correspondence on: Methodological Standards When Reporting From National Databases.

Pubmed   Journal   ReadQx 

Evaluating Serum Free Thiols in Inflammatory Bowel Disease: Contribution of Albumin to Extracellular Free Thiol Status.

Pubmed   Journal   ReadQx 

The Association of Extra-oral Halitosis With Small Intestinal Bacterial Overgrowth in Inflammatory Bowel Disease.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Pancreas

Regarding the risk of hypertriglyceridemic acute pancreatitis.

Pubmed   Journal   ReadQx 

Type 2 Autoimmune Pancreatitis Masquerading as Epstein-Barr Virus Infection: A Case Report.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Am J Clin Nutr

Methylmalonic acid's potential as a prognostic indicator for cancer-related mortality.

Pubmed   Journal   ReadQx 

Selenium from fish consumption may protect against cognitive impairment: could selenoneine be involved?

Pubmed   Journal   ReadQx